【摘要】 本试验应用氨基半乳糖及内毒素,致大白鼠实验性肝坏死,应用肝细胞生长素（HGF）或前列腺素E₁（PGE₁）观察对肝细胞的保护作用,以结晶紫染色法检测鼠血清中肿瘤坏死因子（TNF）活性。结果表明,实验性肝坏死时,血清中TNF活性较对照组明显升高,HGF及PGE₁能保护肝脏,并降低血清中TNF活性。作者认为,TNF与实验性肝坏死发病机制有关,HGF及PGE₁能抑制内毒素诱导的TNF产生,从而防止肝坏死。更多还原

【Abstract】 Galactosamine and lipopolysaccharide （LPS） were used to cause experimental liver necrosis in rats. Hepatocyte growth factor （HGF） and prostaglandin E₁ （PGE₁） were used to protect the experimental liver. Serum tumor necrosis factor （TNF） activity was detected by crystal violetstaining method. A significant elevation of TNF activity was observed in the experimental liver necrosis group but not in the control. HGF and PGE₁ protected the liver and decreased serum TNF activity in rats. The paper suggests that serum TNF may play an important role in the pathogenesis of experimental liver necrosis, that HGF and PGE₁ seem to be a protection of in liver injury by decreasing serum TNF activity.更多还原