【摘要】 本文采用免疫比浊法测定42例冠心病患者和20例健康人血清载脂蛋白A-Ⅰ(ApoA-Ⅰ)、载脂蛋白B(ApoB)含量,同时比较血清脂类和载脂蛋白对冠心病的辨别力,并对血脂和载脂蛋白的相关性进行分析。结果表明:42例冠心病患者血清ApoA-Ⅰ水平明显低于对照组,ApoB水平明显高于对照组。血脂和载脂蛋白单项指标及比值对冠心病的辨别力,最好的指标是ApoA-Ⅰ,其次是ApoB/ApoA-Ⅰ比值。ApoA-Ⅰ和ApoB对冠心病的正确辨别符合率明显优于现用的血脂指标。提示:测定冠心病患者血清ApoA-Ⅰ和ApoB含量有重要的临床实用价值。更多还原

【Abstract】 Serum apolipoprotein A-I and B(ApoA-I, ApoB)were determined in 42 patients with coronary heart disease (CHD)and 20 healthy controls by using immunonephelometry assay (INA) in this study. At the same time, discriminative power of serum lipid and apolipoproteins was compared between patients with CHD an5 controis,and correlatioh between levels of serum lipid and apolipoprotein was analysed. These results indicate that 42 patients with CHD had significantly lower ApoA-I and higher ApoB levels than controls. The patients with old myocardial infarction had significantly lower ApoA-I levels and higher ratio of ApoB/ApoA-I than the patients with angina pectoris. Diseriminant analysis showed that ApoA-I was the best discriminator and that the ratio of ApoB/ApoA-I was the next,both ApoA-I and ApoB had better discriminative power than the conventional vaciables of other lipid.This study indicated that the determination of serum ApoA-I and ApoB levels in patiens with CHD was of significant practical value.更多还原