【摘要】 用药动学-药效学结合模型对氨氯吡咪在家兔体内的处置和效应动力学作定量分析。氨氯吡咪的K_eo,EC₅₀,E_max,S分别为0.040±0.019 min^-1,0.33±0.22 μg/ml,0.22±0.04 ml/min,3.41±0.77,其利尿作用的峰值明显滞后于血药浓度峰值,表明血浆与作用部位属于不同的房室,两者之间存在着一个平衡过程。其滞后时间的长短取决于K_eo的大小。更多还原

【Abstract】 The Pharmacokinetic and pharmacodynamic profiles of amiloride were analyzed by the combined pharmacokinetic and pharmacodynamic model in rabbits, The pharmacodynamic parameters K_eo（the elimination rate constant of the effect compartment）, EC₅₀ （the drug concentration at half maximum effect）, E_max （the maximum drug effect）, S （Hill coefficient） for amiloride were 0.040±0.019 min^-1, 0.33±0.22 μg/ml, 0.22±0.04 ml/min, 3.41±0.77 respectively. Following an iv dose of amiloride, its maximal diuretic effect occurred after the peak plasma drug concentration. This indicates that the plasma and effect site belong to different compartments and the equilibrium between the plasma and effect site is not reached instantaneously.更多还原