【摘要】 用人喉癌手术切除标本建立了裸鼠移植瘤模型,已传至13代。原代移植成功率为66.7％,潜伏期30～70d;鼠间传代移植成功率为100％,潜伏期14～19d,生长稳定。经光学显微镜检查,各代移植瘤组织结构与原人喉癌组织基本一致。电镜检查证明,具有人喉癌特征,癌细胞间有大量桥粒,细胞浆中可见张力原纤维,有的张力原纤维与桥粒相连。细胞表面有较大的指状突,核膜较规则,胞浆中线粒体较多。更多还原

【Abstract】 We have successfully established an animal model of human laryngeal carcinona in BALB/cA nude mice by transplanting subcutaneously small tissue fragments derived fron patient. The tumor tissue was serially trans-planted for 13 generations during 14 months.The tumor incidence for the first generation was 66.7% ( 2/3 ) and in the following generations 100% ( 27/27 ) .Rapid and stable growth was found from the third generation and the characteristic tissue structure of the laryngeal tumor was well retained in the transplanted tumors.The nude mice model would be useful for the basic and experimental therapeutic studies of laryngeal carcinoma.更多还原