【摘要】 应用微孔滤膜法研究巨噬细胞在单核细胞迁移过程中所起的作用 ,结果表明 ,兔腹腔巨噬细胞能够产生单核细胞趋化因子。该因子具耐热性 ,加热至 10 0℃ 10 min仍有活性 ;经透析其活性仍然保存 ;但可被胰蛋白酶灭活 ;对巯基乙醇敏感。提示该因子是一种含关键二硫键的多肽更多还原

【Abstract】 Rabbit peritoneal macrophages conditioned medium were collected and their effects on monocyte migration were investigated ,using micropore filter assay.The results showed that rabbit peritoneal macrophages could secrete a chemotactic factor for the monocyte.This factor was heat stable at 100℃ for 10 min,not dialyzable,but could be inactivated by trypsin and mercaptoethanol.These data suggest that this chemotactic factor is a peptide containing essential S S bonds.更多还原