【摘要】 采用一次性训练被动回避性条件反应——跳台法,观察了益智1号(由何首乌、石菖蒲、葛根、银杏叶、川芎、赤芍等组成)水煎醇沉液对小鼠学习记忆障碍的改善作用。结果表明:益智1号25、50g/kg灌服7d(成人1.6g/kg.d)、能拮抗东茛菪碱0.001g/kg和戊巴比妥钠0.03g/kg对记忆获得的破坏作用,改善氯霉素0.2g/kg和亚硝酸钠0.12g/kg造成的记忆巩固不良、以及改善40%乙醇10ml/kg引起的记忆再现缺失,与脑复康0.1g/kg比较无显著性差异。更多还原

【Abstract】 Yizhi No 1 on memory in mice was studied using one trial Passive avoidance responsesstep-down test, Results indicated that it improved impairment of acquisition of memory produced by scopolamine and phenobarbital,and disruption of consolidation of memory caused by chloramphenicol, and sodium nitrite. It was capable of antagonizing alcohol-induced deficit of memory retrival, as compared with piracetam.更多还原