【摘要】 本文对43例SLE患者和19例健康女性的血清PGE₂、IL-1含量和外周血HLA-DR⁺单核细胞表达率检测研究。结果表明,SLE活动期患者HLA-DR⁺单核细胞表达率（77.3±9.51%）明显高于稳定期患者（52±14.74%）和健康人（52±5.88%）（P<0.O1）。而SLE稳定期患者血清PGE₂含量（298±220pg/ml）显著高于活动期患者（106±64pg/ml）和健康人（113±34pg/ml）（P<0.01）。SLE患者HLA-DR⁺单核细胞表达率与血清PGE₂含量之间呈现较好负相关（r=-0.65,P<0.05）。活动期患者血清IL-1活性水平（2.58±0.62）高于稳定期患者（1.78±0.44）（P<0.05）,但两者血清IL-1活性水平与健康人（1.98±0.30）比较无统计学差异,然而SLE患者血清IL-1活性水平与HLA-DR⁺单核细胞表达率之间也存在弱正相关（r=0.58,P<0.05）。本实验研究表明,SLE患者的HLA-DR⁺单核细胞表达率变化与血清PGE₂和IL-1含量变化之间存在相关性。更多还原

【Abstract】 The expression rate of HLA-DR⁺ monocyte in peripheral blood and con-tent of PGE₂, IL-l in sera or 43 SLE and 19 normal individuals were observed. The re-sults showed that the expression rate of HLA-DR⁺ monocytes averaged 52±5.88% in 19normal individuals. In 46 patients with SLE, HLA-DR⁺ monocytes averaged 77.3±9.51% in 24 active patients, and 52±14.74% in 19 remission patients. There were signi-ficant difference of the HLA-DR⁺ monocytes between active patients, remission patientesand normal individuals （P<0.01）. The PGE₂ content in sera of remission patients （298±220 pg/ml） was significantly higber than that or active patients （106±64 pg/ml） andnormal indiyduals （113±34 pg/ml） （P<0.01）. In SLB patients, there were negative cor-relation （r=-0.65, P<0.05） between PGE₂ content in sera and HLA-DR expressionrate. The IL-l level in sera of active patients （2.58±0.62） was higher than that of re-mission patients （1.78±0.447）（P<0.05）, but the IL-1 level of active and remission pa-tients showed no marked difference from that or the normal individuals （1.988±0.30）.The level of IL-1 and expression rate of HLA-DR⁺ monocytes had weak correlation （r=0.58, P<0.05） in SLB patients, too. These results illustrated that in SLE patients therewas a correlation between the expression rate of HLA-DR⁺ monocytes and content ofserum PGE₂ and IL-1.更多还原