【摘要】 本工作在大鼠口服CCL₄所致肝细胞坏死模型上,比较了丹参与钙拮抗剂异搏定和扩血管药酚妥拉明对肝坏死的保护作用。结果发现,CCl₄引起的肝组织坏死与肝组织钙含量呈正相关（r=0.887,P<0.01）。丹参和异搏定使肝组织坏死程度减轻,肝组织钙含量减少,血浆GPT活性下降,肝组织匀浆MDA含量降低,细胞色素P-450活性升高。酚妥拉明组与损伤对照组比较,各项指标无明显差异。上述结果提示,丹参的作用效果优于异搏定。丹参抗CCl₄所致的肝细胞坏死井非通过扩血管作用,而是发挥其钙拮抗作用实现的。更多还原

【Abstract】 In this study, carbontetrachloride was administered orally to male Wistarrats at a dose of 2.5ml/kg body weight. The protective effects of RSM were comparedwith that of verapamil （a well-known calcium antagonist）, and regitine （a vasodilator）,to study the mechanisms of RSM action. The results showed that a significant correlation between CCl₄-induced liver tissuenecrosis and liver tissue calcium content（r=0.887, P<0.01）. In both RSM group andverapamil group the liver tissue calcium content, plasma GPT activity, liver tissue MDAcontent were all much lower and liver cytochrome P-150 was higher than that in CCl₄injured group （P<0.01）. RSM was more effective than verapamil in protecting liver cellfrom CCl₄-induced hepatocellular necrosis. Morphological and biochemical changs of regi-tine group were similar to those of CCl₄ injured group. The above results suggested that protective effects of RSM on CCl₄-induced liver cellnecrosis were not via vasodilation but by calcium antagonism of RSM.更多还原