【摘要】 将取代四苯基卟啉与胆固醇通过共价键连接,合成了6种卟啉胆固醇酯。经元素分析和波语分析对化合物进行了表征。测定了个别化合物对肿瘤细胞的光动力杀伤和对红细胞的光溶血作用。结果显示,对癌细胞有一定程度的直接杀伤作用,而光敏性很小。更多还原

【Abstract】 Six cholesterol-porphyrins have been synthesized. The photoradiative effect on cancer and the interaction of compounds 5 and 9 with red cells have been examined. The results shown that to some degree, they showed a destructive effect on Ehrlich ascitogenous cells and Mouse ascitic breast carcionma cells directly,but very little photo-hemolytic action.更多还原