【摘要】 通过建立整体结构模式化多因素判别分析法(WSPMDA),对有机磷农药三种构份的亚型进行了有代表性的模式化,进而排列组合成36种整体模式,据有机磷农药诱变性测试资料,用该法推算出各整体模式在6种诱变试验中的预期阳性概率P(M~+),并分析每种构份的亚型模式与诱变性关系的密切程度.观察到三种构份均对有机磷的诱变性几乎在每种试验中都有影响,讨论了如何正确应用所得P(M~+)、还就分析结果结合诱变试验原理推测有机磷诱变分子机理存在三条不同途径。更多还原

【Abstract】 Whole structure patternization multivariant discriminant analysis(WSPMDA)was established for studying the structure-activity relationship of mutagenicity of organophosphorus pesticides(OPPs),of which the 3 constituents were patternized in subtype patterns,and then 36 categories of structural patterns of OPPs were constructed.Predicted mutagenicity probability,P(M+),was calculated for all the categories of the structural patterns of OPPs in 6 mutagenicity tests,and the relationship between the 3 constituents and mutagenicity of OPPs was analyzed.It was found that all the 3 constituents did affect the mutagenicity of OPPs in almost all the 6 tests.The proper application of P(M+)for development of safer new OPPs was discussed.Furthermore,according to the results of WSPMDA and the principles of different tests,it is proposed that there exist 3 different ways for the molecular mechanism of mutagenicity of OPPs.更多还原