【摘要】 本文采用两种实验性心肌梗塞动物模型.观察藻酸双酯钠(PSS)抗心肌缺血的作用。实验结果显示,PSS能降低高位结扎冠状动脉前降支后引起的家兔心电四ST段异常抬高的程度(∑ST)以及病理性Q波出现数(NQ),缩小家兔心肌梗塞范围(MIS).并使血清CPK活性降低;PSS亦能减轻异丙肾上腺素引起的大鼠心电图上缺血性损伤变化.降低心肌CPK活性,提示PSS对心肌缺血性损伤具有保护作用.更多还原

【Abstract】 This study reported the protective effects of poly-saccharide sulphate (PSS) on experimental model of myocardial infaction by high positioned double - ligation of the anterior descending left coronary artery in rabbits, and on ischemic injury of myocardium by intraperi-toneal injection of isoprenaline in rats. The results showed that PSS could decrease the infarct sizes of rabbits model expressed by ECG mappingof ∑ST segment, NST and NQ, and reduce the activities of CPK in serum. It also showed that PSS reduced the severity of myocardial necrosis and the activies of CPK in serum of the experimental rats . It suggested that PSS have the protective effects on ischemic injury of myocardium.更多还原