【摘要】 小鼠皮下注射和灌胃米索前列醇（Mis）的LD₅₀分别是37.1和56.4mg/kg。大鼠灌胃Mis0.6,2和6mg/（kg·d）30d,红细胞和血红蛋白升高,血糖和总蛋白量降低（均在正常范围）;前列腺的脏器系数减小。撤药d15,上述改变均恢复到对照水平。病理检查示Mis导致曲精细管上皮严重受损,生精细胞减少至消失,尤以6mg/（kg·d）组为甚,撤药d15生精细胞增多。提示长期大量应用Mis对雄性生殖系统产生可逆性损伤。更多还原

【Abstract】 LD50 of misoprostol (Mis) were found to be 37.1 (sc) and 56.4 mg/kg (ig) in mice. In rat after Mis 0.6, 2, 6 mg/(kg ?d) were administered ig for 30 d, in comparison with olive oil group, RBC and Hb were high, glucose and total protein were low, the index of prostate was decreased. These changes were restored 15 d after withdrawal. Pathological examination showed that testicular convoluted tubules were damaged severely and germ cell number was decreased, especially at 6 mg/(kg ?d). These pathological changes were restored 15d after withdrawal. The results suggest that Mis 2, 6 mg/(kg ?d) ig for 30 d caused a reversible damage in testes.更多还原