【摘要】 应用COPT、IHA、ELISA检测新流行区44例血吸虫病人吡喹酮治疗前后抗体水平变化。结果,治后6个月,COPT、IHA和ELISA的抗体阴转率分别为47.7％、9.1％和22.7％;环沉率均值由治前27.3％下降至9.9％,IHA和ELISA检测的抗体滴度均有明显下降,治后12个月COPT的阴转率较IHA、ELISA为高,但治后12～18个月3法检测的抗体水平未见继续下降。感染度较高(EPG≥16)的23例患者,治前3法阳性率均为95.7％,治后6月、12个月抗体水平下降幅度COPT明显高于IHA和ELISA。在新流行区COPT近期疗效考核的效果比IHA和ELISA为好。更多还原

【Abstract】 The COPT、IHA and ELISA were used to detect the changes of antibody level in 44 patients with chronic schistosomiasis japonica before and after treatment with praziquantel in a new endemic area. The results showed that antibody negative conversion rate in COPT. IHA and ELISA 6 months after treatment were 47. 7%. 9. 1% and 22. 1% respectively. The positive COPT rate was decreased from 27. 3% to 9. 9%. The antibody geometric mean reciprocal titer(GMRT) of ELISA and IHA were all decreased in 6 months after treatment. The rate of negative conversion of COPT was much higher than that of ELISA and IHA in 12 months after treatment. But there was no continuous drop in antibody level with any method 12-18 months after treatment. In 23 patients with higher infection intensity the positive rate of COPT, ELISA and IHA was 95. 77% before treatment, and at 12 months after effective chemotherapy, the negative conversion rate of COPT was greater than that of ELISA and IHA. Therefore, COPT is better than either IHA or ELISA in evaluating the effect of chemotherapy within a short period.更多还原