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兽药新制剂促反刍LD50和安全性试验

LD50 and Safety Test of A New Veterinary Preparation ——“Injectio Cufanchui”

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【作者】 扈文杰刘清玉李富娥孔洁

【Author】 Hu Wenjie Liu Qingyu Li Fu’ e Kong Jie(Department of Veterinary Science,Northwestern Agricultural University,Yangling,Shaanxi,China,712100)

【机构】 西北农业大学兽医系西北农业大学兽医系 陕西杨陵 712100陕西杨陵 712100陕西杨陵 712100

【摘要】 对兽药新制剂促反刍注射液(CFC)进行了急性毒性试验、局部刺激试验和过敏性试验。用90只小白鼠按点斜法试验设计,以剂间比为1:0.8的7个剂量组测得CFC腹腔注射的LD50为35.05mL/kg,95%置信区为31.2~39.39 mL/kg,相当于制剂主药总量5054~6389mg/g符合化学物质分级低毒级标准。证明CFC为低毒药物,无过敏性,比较安全。因此有轻度刺激性,适于静脉注射。

【Abstract】 The Injectio Cufanchui(CFG) ,a new veterinary preparation’s a composition injection for cure on Atonia Proventriculorum and Impalctio Rumin in cows and sheep. The acute toxicity and local stimulate and allergia of CFC were tested. The LD50 of CFC for peritoneal injection was tested by synthesis method (point -slope method) in 90 mice. The results indicate that the LD50 value is 35. 05mL/kg. 95% of confidence area is 31. 2~39. 39mL/kg,which is as high as total content of drugs 5054~6389 mg/kg. The preparation was proved to be low toxiy and safe veterinary drug free of allergy. Therefore CFC can be intravenusly intected because of its slight local stimulate reaction.

  • 【文献出处】 西北农林科技大学学报(自然科学版) ,Journal of Northwest Sci-Tech University of Agriculture and Forestry , 编辑部邮箱 ,1993年04期
  • 【被引频次】3
  • 【下载频次】47
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