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乙肝患者血、尿β2微球蛋白和尿白蛋白、IgG的检测及意义

EXAMINAION AND ASSAY OF BETA2 MICROGLOBULIN, URO-ALBUMIN, IgG AND THEIR SIGNIFICANCES IN B-HEPATITIS PATIENT

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【作者】 陈永平; 董庆加; 丁鸿燕;

【Author】 Chen Yongping (Department of Infectious Disease, the 1st Affiliated Hospitll)

【机构】 温州医学院附属一院感染科; 温州医学院附属一院感染科;

【摘要】 78例慢乙肝患者尿β2微球蛋白(β2MG),尿白蛋白(ALB)及IgG明显高于正常组,慢活肝组亦显著高于慢迁肝组。血β2MG各组间相近。慢活肝患者尿IgG增高显著,与尿ALB呈高度正相关(r=0.95,P<0.01),16例慢活肝活动期尿β2MG、ALB及IgG略高于恢复期。提示慢乙肝患者可合并肾脏病变,其严重程度符合免疫损伤规律。并认为慢活肝患者的肾功能受损可能是一种不可逆状态。而尿β2MG、ALB及IgG的检测可较早发现其肾脏损害。

【Abstract】 The contents of urinary beta2 microglobulin (β2MG ) , urinary albumin ( ALB) and IgG in 78 cases of the chronic B-hepatitis group was significantly higher than that of the normal group. That in the chronic active hepatitis was also significantly higher than that in the chraaic protractive hepatitis. Beta2 microglobulin in blood was approximative among every grous. Urine IgG was increased predominantly in chronic active hepatitis group. IgG and ALB in urine showed highly positive correlation ( r = 0.95, P<0.01 ) . Urine (β2MG. ALB and IgG in 16 cases of the active stage of the chronic active hepatitis were slightly higher than that in the convalescence. It suggested that patients of chronic active hepatitis could be complicated with the renal lesions. The severity accorded with the role of the immunologic lesions. It is considered that the damage of the renal function in the chronic active hepatitis might be an irreversible status, whereas the estimation of (β2MG, ALB and IgG in urine might earily find the renal lesions.

  • 【文献出处】 温州医学院学报 ,Journal of Wenzhou Medical College , 编辑部邮箱 ,1993年01期
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