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急性低气压缺氧对小鼠肠系膜微循环的影响

Effects of Low Atmospheric Anoxia on Mesenteric Microcirculation in Mice

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【作者】 周培恩; 章向红; 刘杏芳; 谌辉;

【Author】 Zhou Pei’en, et al (Hygiene School of Wuhan City, Wuhan 430030)

【机构】 武汉市卫生学校; 武汉市第一医院 430030; 430030;

【摘要】 34只小鼠经快速低气压性缺氧处理,引起肠系膜微循环明显损害。包括:1.微血管轮廓及分支状态改变;2.血管管径粗细不匀;3.微小动脉细直;4.血管内红细胞聚集;5.血液流态改变;6.血管周围出血及渗出。电镜下见到微血管内皮细胞明显损害及血浆血细胞分离。提示:以上损害程度与低气压程度及持续时间有关。

【Abstract】 34 mice were studied. After rapid management of low atmospheric anoxia (0. 06~0. 067 MPa for 1 or 2hours), it gave rise to abnormal changes in mesenteric microcirculation, including: 1. Change of profile and ramifications; 2. Irregular diameters; 3. Thinning and straight of arterioles; 4. IRCA; 5. Change of blood flowing state; 6. Perivascular bleeding and extravasation with further developping after the pathogenic factor was removed. Under electronic microscope, there was obvious pathologic changes of the endothelial cells accompanying with dissociation of blood corpuscle and plasma. The damaging degree is correlated to the lowering degree of atmospheric anoxia and its duration.

  • 【文献出处】 微循环学杂志 ,Chinese Journal of Microcirculation , 编辑部邮箱 ,1993年03期
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