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三硝基甲苯对大鼠胆固醇和甘油三酯影响的研究

Studies on the Effects of Trinitrotoluene on Cholesterol and Triglyceride in Rats

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【作者】 赵春艳李爱华常元勋江泉观

【Author】 Zhao Chunyan,et al.(Dept.of Occupational Health,School of Public Health,Beijing Medical University,Beijing 100083)

【机构】 北京医科大学劳动卫生教研室北京医科大学劳动卫生教研室 100083100083100083

【摘要】 不同剂量的三硝基甲苯(TNT)染毒大鼠,从染毒后第四周开始,各剂量组血清甘油三酯的含量显著下降;从染毒后第六周开始,各剂量组肝脏甘油三酯和胆固醇的含量明显低于对照组,血清胆固醇含量明显高于对照组;至染毒后第八周各指标均未见恢复。表明 TNT 对大鼠的脂代谢有一定的影响。

【Abstract】 The contents of triglyceride in serum of rats were decreased significantly at all doses oftrinitrotoluene(TNT)exposure after 4 weeks of TNT exposure.After 6 weeks of TNT exposu-re,the contents of cholesterol and triglyceride in livers of rats in each treated group were si-gnificantly lower than those in control;but the contents of cholesterol in serum were increa-sed significantly.No index was found to be recovered after 8 weeks of TNT exposure.The re-sults indicate that TNT could exhibit toxic effects on lipid metabolism.

【关键词】 三硝基甲苯甘油三酯胆固醇血清肝脏大鼠
【Key words】 TrinitrotolueneCholesterolTriglycerideSerumLiverRat
  • 【文献出处】 卫生毒理学杂志 ,Journal of Health Toxicology , 编辑部邮箱 ,1993年01期
  • 【被引频次】4
  • 【下载频次】35
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