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东莨菪碱对豚鼠庆大霉素中毒性耳聋的预防作用
PREVENTIVE EFFECT OF SCOPOLAMINA ON GENTAMYCIN INDUCED DEAFNESS IN GUINEA PIGS
【摘要】 本研究以耳廓反射、耳蜗生物电和耳蜗铺片为指标,观察东莨菪碱对豚鼠庆大霉素中毒性耳聋的预防作用。实验结果表明东茛菪碱在听力下降程度及发病时间等方面均能减轻庆大霉素的耳毒性作用。
【Abstract】 The experiments have been performed using Preyer’s reflex, cochlear potential, and surface preparation of the cochlear as indexes of the auditory function. The results indicate that the scopolamina reduces ototxicity produced by gentamycin on the degree of hearing loss and the time of hearing loss to occur.
【关键词】 庆大霉素;
东莨菪碱;
耳毒性;
耳廓反射;
耳蜗电位;
【Key words】 gentamycin; scopolamina; ototoxicity; Preyer’s reflex; cochlear potential;
【Key words】 gentamycin; scopolamina; ototoxicity; Preyer’s reflex; cochlear potential;
【基金】 上海市卫生局基金
- 【文献出处】 泰山医学院学报 ,Journal of Taishan Medical College , 编辑部邮箱 ,1993年01期
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