【摘要】 选取本院1990年2月～1992年2月经细胞学、组织学证实的非小细胞肺癌63例,用MAP方案治疗取得满意效果。其中腺型占65.1％,鳞型及低分化型分别占25.4％和9.5％。化疗后总有效率为39.7％(25/63)均为PR,1例PD。Ⅱ、Ⅲ、Ⅳ期有效率分别为60.0％、42.4％和32.0％;鳞型和腺型有效率分别为37.5％和34.2％,低分化型非小细胞癌最佳达83.3％,P值均>0.05。副反应有脱发,达100％,以中度为主,胃肠道反应占98.2％,以轻中度为主,88.9％血像受抑制,3例有心律不齐,未见肝肾功能异常。更多还原

【Abstract】 The incidence and mortality of primary bronchogenic carcinoma are on the increase in Shanghai. From Feb. 1990 to Feb. 1992, the efficacy of Mitomycin （MMC 6 mg/m².d₁）, Adriamycin （ADM 50mg/m².d₁）and Cisplatinum （C-DDP 70mg/m² d₁） was investigeted in 63 patients with non small cell lung cancer （NSCLC） in Shanghai Chest Hospital. All patients were eva- luated with the criteria by WHO for CR, PR, NC,PD and side effects applied during the ana- lysis. The male to female ratio was 2.1:1, with an average age of 57.5 years （range 33-78 years）. Histological subtypes were defected to be squamous cell carcinoma （Sq.25.4%）, ade- nocarcinoma （Ad 65.1%） and undifferential NSCLC （9.5%）. The overall response rate was 39.7%（25/63）. PR abservation was made in 25 patients; NC was seen in 37 patients. Only one patient was PD, and no CR was found. The response rate at stages Ⅱ, Ⅲ, and Ⅳ was 60.0%, 42.4% and 32.0% respectively, （P>0.05） nevertheless, that of Sq, Ad and undifferen- tial NSCLC was 37.5%, 34.2% and 83.3% respectively, （P>0.05）. The side effects observed in these patients are as follow. 100% of the patients had mode- rate alopecia; 98.2% had moderate and mild neuser and vomiting and 88.9% developed leuko- cypenia of different degrees. Three patients suffered from arrythmia. No abnormal function in liver and kidney was found.更多还原