【摘要】 理论上认为胆固醇逆向转运的速率与动脉粥样硬化(AS)程度呈负相关.但目前尚无完善的测试血浆脂蛋白-胆固醇体内代谢的方法.我们运用同位素~3H-胆固醇示踪方法,建立房室模型,选取健康兔与AS免对照,研究血浆脂蛋白转运胆固醇能力的差异.并结合AS兔主动脉斑块程度对比.结果验证了上述理论,此法如改用短半衰期同位素或稳定性同位素标记的胆固醇,就可用于人体,这可为临床判断AS程度提供一种无创性的新方法.更多还原

【Abstract】 In general, the rate of reverse cholesterol transport are strongly correlated with the development of .AS. but quantitative determination is lacking. By means of the 3H-cholesterol trace method. a three compartment model is established to describe cholesterol metabolism among plasma lipoproten. liver. and extrahapetic tissue in vivo. According to the experimental data. the rate constants from one compartment to another and the dynamic curves in each compartment have been estimated by means of the theory of system identification. These model parameters can be used to assess the ability of plasma lipoproteins in transfering cholesterol. Based on the results of the experiments, it is found that the ability of reverse cholesterol transport in the AS group was weaker than that of the control group. It is also noted that the rates of cholesterol transport are highly negative correlated with the degree of AS. We expect that this research will provide a new method and enlightenment on clinical prediction, diagnosis and treatment of AS.更多还原