节点文献

赤爱胜蚯蚓(Eisenia Foetida Sarigny)纤溶酶的研究——Ⅲ.消化道吸收的研究

Study on Earthworm Fibrino lysin Activity of Eisenia Foetida Sarigny ——Ⅲ. Study on Intestinal uptake experiment of Earthworm Fibrinolysin

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 Zhang Yunhu Yang Zhixing(The Institute Applied Microbiology of Academy of Sciences of Heilongjiang, Harbin)Yiao Hanbiiig(The T echnico-physical Institute of ceutical products of Heilongjiang Provence, Harbin)Yang Ming(The Institute for the Control of Pharma-ceutical Products of Heilongjiang P rovence, Harbin)Dong Guihuan Zhao Keqiang(The Wei Jian Pharmaceutical Fact a ry, H ar bin)

【机构】黑龙江省科学院应用微生物研究所；黑龙江省科学院技术物理研究所；黑龙江省药品检验所；哈尔滨市卫健制药厂；哈尔滨市卫健制药厂哈尔滨；哈尔滨；哈尔滨；

【摘要】本文通过用¹²⁵I(NaI¹²⁵标记的纤溶酶所作的家兔消化道的吸收实验研究及用3P87药代动力学程序的微机处理,确定了纤溶酶的消化道吸收的药时曲线;在血液中的消除半衰期为137分钟;消除速率常数为0.00506立升/分钟;峰浓度时间约为170分钟和其生物利用度约为39％的结果。为使纤溶酶制成肠溶溶栓酶片提供了临床应用研究的依据。更多还原

【Abstract】 This article roborted that the Fibrinolysin has been labelled by isotope 125I. The labelled products was as reagent for study of intestinal uptake experiment of rabbits. The Data were processed using 3P87 pharmacadynamics programme and a computer. The results r.s following. Have established a drug-time carve of inctnstical uptake of Fibrinolysin. The eliminate half life of it in blood is about 137 minuts. The eliminate constant is about 0.0050061/min.The peak concentration time is about 170 minuts, and the biological utilization coeff-icient is about 39%. So these results earr provids the theorg base for use of fibr-iaolysin in therapy of dcscase.更多还原

【关键词】 NaI¹²⁵；药时曲线；消除半衰期；生物利用度；
【Key words】 125I isotope； Drug-tine curve； Elimitation half life； Biological utilization coefficient；

【文献出处】生物技术 ,Biotechnology , 编辑部邮箱 ,1993年05期

【被引频次】8
【下载频次】71

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献