【摘要】 本文检测甲亢甲减实验大鼠血浆、心房心钠素（ANP）,血浆肾素活性、血管紧张素Ⅱ和醛固酮含量,并与正常大鼠进行比较。发现（1）甲亢大鼠血浆 ANP 显著升高,心房 ANP 显著低下,甲减大鼠两者呈相反变化:（2）血浆 ANP 和血清 T₄呈正相关,（3）甲亢和甲减大鼠肾素活性和血管紧张素Ⅱ分别呈明显升高和降低;醛固酮水平则无明显变化。上述结果提示甲亢时心房释放 ANP 增加,甲减时释放减少;异常甲状腺功能状态下,血浆 ANP 与肾素-血管紧张素-醛固酮系统相互作用对维持体液平衡有一定意义。更多还原

【Abstract】 The concentrations of plasma and atria atrial natriuretic peptide（ANP）,plasmarenin activity（PRA）,agiotension_Ⅱ(A_Ⅱ),and,aldosterone（ALD）in experimental hy-perthyroid and hypothyroid rats were measured,and compared with euthyroid rats.Plasma ANP was higher（P<0.01）in hyperthyroid rats and lower（P<0.05）in hypo-thyroid rats than that in euthyroid rats.ANP concentration in the atria was lower（P<0.01）in hyperthyroid rats and higher（P<0.05）in hypothyroid rats than thatin control group.An positive correlation was found between the Plasma ANP and se-rum T₄ in different thyroid states（n=28,r=0.839,P<0.01）.Plasma PRA and A_IIwas higher（P<0.01 and P<0.05）in hyperthyroid and lower（P<0.01 and P<0.05）in hypothyroid rats than that in euthyroid rats.There were no significant difference（P>0.05）in plasma ALD levels among hyper-,hypo and euthyroid rats.The resultssuggest an increased release of ANP from the atria in hyperthyroidism and a decreasedrelease of ANP from the atria in hyperthyroidism and the effects of ANP and renin-agiotension-aldosterone system on maintaining the equilibrium of water and electroly-tes may be an important in thyroid dysfunction.更多还原