【摘要】 应用半乳糖-半乳糖胺检测法对118份直肠粘液标本作了检查。在30例大肠癌病人中其阳性率达90％,在65例肠粘膜正常人中,其阴性率达92.3％;另外20例大肠息肉病人中,其阳性率为15％,3例溃疡性结肠炎病人中阳性率为66.7％。结果表明:该法有较高的敏感性(90％)和特异性(92.3％),方法简便,结果易重复,在大肠癌普查中具有较大的应用潜力;在大肠息肉和溃疡结肠性炎中也有一定的阳性率,提示该法可用于某些大肠癌癌前状态恶变的监测。更多还原

【Abstract】 Oolorectal cancer is a common malignant tumor of the digestive tract with a high morbidity and mortality rate in China as well as in Western countries. The commonly used method in laboratory screening for colorectal cancer is the stool guaiac test, which is based on bleeding from tumors. But it has been reported that this test carries a high rate of false-positive results (20%} and low rates of actual-positive results(4.1%). By the detection of T-antigen (gialic acid free β-D-Gal(1→3)-D-Gal NAC), which is present in the mucus of colorectal neoplasmas, we found a positive rate of 80 % in 30 cases of colorectal carcinomas and 92.3 % of negative rate in 65 persons who had no clinical evidence of colorectal neoplasms. In two precancerous groups, polyps (20 cases) and ulcerous colitis (8 cases), there were also 8 and 2 positive results respectively. This result indicates that the method has high sensitivity and specificity in the detection of colorectal cancer. Also, it has some positive rates in the study of precancerous stage. Therefore, it can be used as routine screening test for colorectal cancer.更多还原