【摘要】 用大鼠胸主动脉制备成保存内皮细胞和去除内皮细胞两种血管条标本,以 Tyrode 液灌流。两种血管条在10^-7mol/L NE 或50 mmol/L 高钾作用下显著收缩,5～10 min 后依次加入0.01、0.1、0.25、0.5 mg/ml 的熊胆,每次给药间隔10min。观察到两种标本均显示相似幅度的舒张,这种作用随熊胆浓度的增加而增加。0.5 mg/ml 的熊胆可以完全对抗10^-7mol/LNE 所致的收缩,而使高钾所致的收缩张力下降50%左右。熊胆对两种血管条的舒张作用无显著差异（P>0.1）。并证明熊胆对血管的舒张作用不依赖于血管内皮细胞。更多还原

【Abstract】 Two groups of vascular strips were prepared with aorta thorcalis of the rat.The vascu- lar endothelium was intact in one group and removed in the other.The two types of prepara- tions were superfused with Tyrod’s solution.Under the background of the vascular contrac- tion induced by NE(10^-7 mol/L) or high K⁺ （50 mmol/L） bear bile caused a similar,dose- dependent relaxation in both groups.Bear bile of 0.5 mg/L could completely counteract the vascular contraction induced by NE but reduced the developed tension,caused by perfusate containing K⁺ of 50 mmol/L by 50%.The relaxant effect of bear bile in both groups of vas- cular strips were not significant（P>0.1）.This study suggested that the relaxant effect of bear bile on the blood vessel was not depended on the presence of the vascular endothelium.更多还原