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类风湿性关节炎外周血淋巴细胞亚群的观察

An Observation on Lymphocyte Subgroups in Peripheral Blood of the Rheumatoid Arthritis Patients

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【作者】 黄仰模陈纪藩廖世煌陈灿林昌松关彤夏海燕王培训梁瑞燕曹柳英文万逢

【Author】 Huang Yangmo Chen Jifan Liao Shihuang Chen Chan Ling ChangSong Guan Tong Xia Haiyian First Affiliated Hospital Wang Peixun Liang Ruiyian Cao Liuyiug Laboratory of Immunology Wen Wanfeng Guangdong Provincial Hospital

【机构】 广州中医学院第一附属医院综合科广州中医学院第一附属医院综合科广州中医学院第一附属医院免疫研究室广东省人民医院

【摘要】 采用单克隆抗体免疫技术,检测36例类风湿性关节炎(RA)患者外周血淋巴细胞亚群。结果显示T细胞亚群OKT3、OKT4、OKT8比健康成人组降低,P值分别为P<0.01、P<0.05、P<0.01,OKT/OKT8和B细胞略升高,但同健康成人组比较无显著性差异(P均>0.05)。气血不足型与肝肾亏虚型与正常组比较,结果与RA全组基本相同,只有OKT4下降同正常组比较P>0.05。气血不足型与肝肾亏虚型组间对比无显著性差异。结果表明,按中医分型的RA患者淋巴细胞亚群无差别。气血不足型与肝肾亏虚型RA患者的细胞免疫功能均属紊乱,细胞免疫调节功能紊乱同RA的发病有关。

【Abstract】 By using monoclone antibody immune technique, the lymphocyte subgroups in the peripheral blood of 33 healthy adults and 36 rheumatoid arthritis (RA) Patients were examined. The results showed that the T-lymphocyte subpgroups, OKT3, OKT4 and OKT8, in RA patients were lower than those of healthy subjects (P<0.01, <0.05 and <0.01 respectively), and the RA Patients’ OKT4/OKT8 and B-cells were higher but the difference was not significant (P>0.05). There was no difference in the lymphocyte subgroups between those with deficiency of qi and blood and those with deficiency of liver-yin and kidney-yin, although the immunoregulation function of both types was disordered. It is believed that the pathogenesis of rheumatoid arthritis is related to the disorder of cell immunogic function.

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