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类风湿性关节炎外周血淋巴细胞亚群的观察
An Observation on Lymphocyte Subgroups in Peripheral Blood of the Rheumatoid Arthritis Patients
【摘要】 采用单克隆抗体免疫技术,检测36例类风湿性关节炎(RA)患者外周血淋巴细胞亚群。结果显示T细胞亚群OKT3、OKT4、OKT8比健康成人组降低,P值分别为P<0.01、P<0.05、P<0.01,OKT/OKT8和B细胞略升高,但同健康成人组比较无显著性差异(P均>0.05)。气血不足型与肝肾亏虚型与正常组比较,结果与RA全组基本相同,只有OKT4下降同正常组比较P>0.05。气血不足型与肝肾亏虚型组间对比无显著性差异。结果表明,按中医分型的RA患者淋巴细胞亚群无差别。气血不足型与肝肾亏虚型RA患者的细胞免疫功能均属紊乱,细胞免疫调节功能紊乱同RA的发病有关。
【Abstract】 By using monoclone antibody immune technique, the lymphocyte subgroups in the peripheral blood of 33 healthy adults and 36 rheumatoid arthritis (RA) Patients were examined. The results showed that the T-lymphocyte subpgroups, OKT3, OKT4 and OKT8, in RA patients were lower than those of healthy subjects (P<0.01, <0.05 and <0.01 respectively), and the RA Patients’ OKT4/OKT8 and B-cells were higher but the difference was not significant (P>0.05). There was no difference in the lymphocyte subgroups between those with deficiency of qi and blood and those with deficiency of liver-yin and kidney-yin, although the immunoregulation function of both types was disordered. It is believed that the pathogenesis of rheumatoid arthritis is related to the disorder of cell immunogic function.
- 【文献出处】 广州中医学院学报 , 编辑部邮箱 ,1993年03期
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