【摘要】 本文提供了N_b-甲基四氢海曼和合成中间体,共十个化合物的~1H NMR谱。各谱线的归属依据它们的2D NMR的同核二维相关谱,COSY指定。根据NOE效应,指定了化合物的构型。借助分子模型,讨论了可能的构象。更多还原

【Abstract】 Using Pictet-Spengler condensation, ammonification, methylation, dehydration and decyanation, Nb-methyl -tetrahydroharman and the synthetic intermediates 1S,S、1S,R、2S,S、 2S, R、3S,S、3S,R、4S,S、4S, R were obtained. Their 1H NMR spectra were assigned based on COSY spectroscopy and their configurations of 1-C were determined by NOE experiments. It was shown that for all of the S, S isomers there were NOE relationships between 1-H and 3-H and for all of the S, R isomers NOE relationships between 1-CH3 and 3-H. Based on the results of NOE and the help of Dreiding stereomodels their conformations were discussed.更多还原