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β2—MG 测定对高血压病肾脏损害诊断价值的初步探讨
PRELIMINARY STUDY ON DIAGNOSIS VALUE OF β,-MG DETERMINATION FOR INJURED KIDNEy OF PATIENTS WITH HIGH BLOOD PRESSURE
【摘要】 本文对60例高血压病用放射免疫测定法检测血、尿β2—MG,并同步检测血 BUN、Cr、PSP 试验,结果显示:Ⅱ、Ⅲ期高血压与对照组比较:血β2—MG 与 BUN、Cr,尿β2—MG 与 PSP 试验、尿旦白有非常显著性差异(P 值均<0.01),故β2—MG 增高是反映高血压病肾小球与肾小管损害敏感指标,并初步证实高血压早期已有肾功能损害改变。按目前常规检测方法高血压性肾损害阳性率低,为了揭示高血压病肾损害,我院用放射免疫法测定血、尿β2—MG,并与血 BUN、Cr、PSP 试验(静脉法),尿旦白相关性进行显著性测验。
【Abstract】 β2—MG determination of blood and urine for 60 patients and synchro-nous Cr,PSP determination of blood were made by radioimmunoprecip-itation assay.The results are as follows:High blood pressure at Ⅱ sta-ge was compared with that at Ⅲ statge,there is a marked difference inurinary protein(P<0.01)in β2—MG,Bon and Cr blood test,and β2—Mgand PSP urine test.Therefore,the increase in β2—MG value is an indexof sensibility that marks the level of damage in glomerulus and renal t-ubules in high blood pressure,and conforms the impairment of renal fun-ction at the early stage of high blood pressure.
- 【文献出处】 石河子医学院学报 , 编辑部邮箱 ,1993年01期
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