【摘要】 利用XbaⅠ限制性内切酶、墨迹杂交对24例正常人及35例NIDDM患者的白细胞基因组DNAGT基因进行了分析。结果显示了X₁ 5.4kb、X₂ 5.0kb 两个多态性的片段。统计学处理表明X₁、X₂等位基因频率及基因型频率在正常人及NIDDM 患者之间的分布无显著性差异,因而此多态性尚不能作为NIDDM 患者的遗传标志,提示GT 基因和NIDDM 之间可能没有关联。更多还原

【Abstract】 A DNA sequence polymorphism of 24 controls and 35 patientswith NIDDM revealed by digestion of genomic DNA with the endonucleaseXbaI and Southern blot hybridisation with a complementary DNA clone forhuman glucose transpo（?）ter（GT）,yields two alleles（sizes 5.4kb,the X₁allele;5.0kb,the X₂ allele）.There are no significant difference of theallele and genotype fre（?）uencies（%）between the control and the NIDDMgroup（P>0.05）.It is suggested that the polymorphism of the GT genemight not be defined as the genetic marker of the NIDDM and there isprobably no association Letween the GT gene and NIDDM.更多还原