【摘要】 本文检测了23例维持性血液透析(血透)患者T淋巴细胞产生的白细胞介素2(IL-2)和白细胞介素2受体(IL-2R)活性。结果23例患者IL-2和IL-2R活性显著低于正常对照组(n=40):11例患者血透后IL-2及IL-2R活性比透析前增加,10例患者经3个月规律血透后,IL-2和IL-2R活性无显著变化。结果表明:维持性血透患者细胞免疫受损,包括T细胞产生IL-2能力和IL-2R活性低下,充分透析能提高IL-2和IL-2R活性,但长期血透无助于改善IL-2和IL-2R活性。更多还原

【Abstract】 The activities of interleukin-2(IL-2) and the prolification activities of interleukin-2 receptor (IL-2R) in 23 patients on maintenance hemodialysis were masured. The results showed that the activities of IL-2 and IL-2R in patients were 1. 38+0. 52 and 10. 85+17. 78,respectively,and it was significantly lower in comparison with normal controls (n = 40,2. 52+1. 69,22. 54+11. 53 respectively) (P<0. 01).The activities of IL-2 and IL-2R in patients increased significantly after dialysis (P<0. 05). But activities of IL-2 and IL-2R in patients were not different between before and after 3 months reglar hemodialysis (P>0. 5). It is concluded that the impairments of cell immune response in maintenance hemodialysis patients include the ability of T cell IL-2 production and the proliferation activities of IL-2R. A full dialysis can improve the activities of IL-2 and IL-2R in patients,but long term hemodialysis is not able to recover them.更多还原