【摘要】 推广应用MDT后用NT—O—BSA～ELISA检测了1715名麻风接触者和6例新病人血中的抗PGI—IgM抗体。1715例接触者中的抗体阳性率分别为:开始MDT前33.4％,用MDT 2～24个月32.82％。用MDT后48个月21.84％(P<0.001);6例新病人在推广MDT 5年时OD下降72.74％;连续观察243例抗体阳性的接触者,2～5年共发病7例(BT 1例,BL 4例,LL 2例)。结果说明:1.接触者和病人抗体水平的高低与用MDT的时间长短有关:2.抗PGI—IgM抗体检测可用于对疗效的监测;3.用MDT后不同时期接触者的抗体OD比较,对寻找传染源,评价麻风防治效果有参考价值;4.观察接触者抗体OD值的变化,对预测其是否发病有重要意义。更多还原

【Abstract】 NT-O-BAS ELISA has been used to determination of anti-PGL-1 IgM antibody in the sera of 1715 contacts with leprosy and six new cases of leprosy before and after wide application of MDT.The positivity rates of the antibody among the contacts was 33.4% before MDT,32.82% 2-1 months after MDT and 21.84% 48 months after conpletion of MDT.The OD values decreaded by 72.74% among six newly detected cases of leprosy the fifth year after introduction of MDT.Among 243 contacts with the positivity seven new cases of leprosy have been found for two to five years of contineous follow-up,including BT one,BT four and LL two.更多还原