【摘要】 通过胃粘膜的损害与胃癌发生关系的实验研究,发现胃粘膜反复损害,常导致不全修复及再生型异型增生。后者有4个类型,即Ⅰ型(糜烂面型)、Ⅱ型(粘膜内型)、Ⅲ型(溃疡边缘型)及Ⅳ型(舌状型)。其中尤以Ⅱ型为多见。结果显示:①在不同实验组再生型异型增生的出现频率与腺癌发生率互为一致;②与始发癌在形态上可见移行过渡;③在异型病变的局部出现早期癌变;④由Ⅱ型癌变而来的早期胃癌常保持着癌巢为大量纤维组织所分隔和包绕的形态特征。本研究论证了再生型异型增生为胃癌的一型重要癌前病变。这型病变亦见于人体材料,因此认为有关其癌前意义应予以重新认识。更多还原

【Abstract】 Regenerative dysplasia of gastricmucosa is such a dysplasia that apperared during ??the process of regeneration and repairment aftertrauma.It was formerly considered as a tran-sient regenerative change with no precanceroussignificance in general,In a series of animal ex-periments on the relationship between the repeat-ed trauma of gastric mucosa and carinogenesis ofthe stomach,it was found that regenerative dys-plasia occurrred frequently and appeared in 4types,namely:Ⅰ.erosion surface type;Ⅱ.intramucosal type;Ⅲ.ulceredge type;Ⅳ.tongue-like type.Type Ⅱ was the most commonone.Based on the following evidences,it wasproposed that regenerative dysplasia of gastricmucoas was an important precancerous lesion:1.The incidence of regenerative dyplasia corre-lated significantly with the rate of adenocarcino-ma in rats of all experimental groups;2.Mor-phological transitional patterns from typical re-generative dysplasia to initial cancer did exist;3.Malignant change was ofter found in a focalarea of dysplasia;and 4.Early gastric cancerderived form malignant changes of type Ⅱ oftenhad a similar characteristic apperance as shownby cancer nests separated or surrounded by largeamount of fibrous tissues.Moreover it also couldbe found in human gastric cancer specimens.Thus a new recognition on its important precan-cerous significance was obvious.更多还原