【摘要】 本文12例冠心病伴3°房室传导阻滞（3°A-VB）.其中5例有阿斯综合征（ASS）发作。以氯茶硷静脉滴注治疗,总有效率75%。对有诱因、急起发作的效果更好,避免了心脏临时起搏。疗效机制:根据腺苷对心脏的作用是通过心肌细胞表面受体介导产生负性变时、变导和变力作用.而氨硷与腺苷对心肌细胞 A₁受体起竞争性拮抗.逆转了腺苷介导的3°A-VB.转为正常房室传导。氨茶硷可作为希司束上阻滞的首选治疗。更多还原

【Abstract】 This paper reported 12 cases of clinical coronary heart disease with third de-gree atrioventricular block（3°A-VB）,and among them,5 cases were complicated by Adam-Stokes Syndrome.They were therapied by aminophylline（500 mg in 5% glucose solution 250ml）with intravenous drip.The rate of cure was 75.0%.This method of therapy in 3°A-VB wasespecially effective in the patients who had inducements or immediate attack,and thus cardiacpacemaker was saved.The action of adenosine appeared to mediate the negative chronotropic,dromotropic（e.g,A-V block）and inotropic actions through the interaction of receptors presentin cardiomyocytes.Aminohylline is an adenosine antagonist,it competitively antagonazes car-diomyocytic A₁ receptor-mediated actions of adenosine（e.g,A-V block）,therefore it can recov-er normal atrioventricular conduction.Aminophylline may be used as the first-choiced drugs forthe treatment of 3°A-VB.更多还原