【摘要】 <正>光敏诊治恶性肿瘤,目前临床上普遍使用的光敏剂是血卟啉衍生物(HPD),但它滞留于皮肤中的量较多,排出缓慢,患者容易产生皮肤光毒反应。1985年Ben-Hur等在中国仑鼠细胞实验中表明氯铝酞菁是一种有效的哺乳动物细胞光敏剂,并指出已有二种酞菁衍生物(铜酞菁和铀酸基酞菁)被选作小鼠脑瘤定位之用。国内蔡怀新等人于1988年研制出新光敏剂磺化铝酞菁,并对具光敏特性及其对人体肝癌细胞的杀伤作用做了实验研究。本文为进一步研究磺化铝酞菁对癌的光敏诊断价值,用磺化铝酞菁对615近交系小鼠移植瘤——乳腺癌(Ca761)更多还原

【Abstract】 Fluorescence spectrum of transplanted tumour (mammary cancer), normal skin and gastric mucosa injected with AlSPc plus excited by dye laser ( λ=607 nm) were studied in 18 mice. The main fluorescence peak of the tumour tissues spectra are located at about 681. 9 nm, whereas this peak of normal skin are located around 682. 7 nm, and the grastric muoosa are at 682. 2 nm. The fluorescence intensity of the tumour than normal akin is 7. 5 : 1 and the fluorescence intensity of the tumour than normal grastric mucosa. It has demonstrated selective localization and retention of AlSPc in cancerous tissues and AlSPc was less cytotoxic to cells. It may become a new potential photosensitizer in PDT of cancers.更多还原