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Effect of Endothelin, Angiotensin Ⅱ and ANP on Proliferation of Vascular Smooth Muscle Cells and Cardiomyocytes

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【Author】 WU Jian-Ming CHENG Tong SUN Shuang-Dan NIU Da-Di ZHANG Ju-Xin WANG Shu-Heng TANG Jian TANG Chao-Shu (Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University, Beijing 100083, PRC)

【机构】 Laboratory of Cardiopulmonary Endocrinology； Beijing Medical University； Beijing 100083； PRC； PRC；

【摘要】 <正> By means of cell culture, ~3H-thymidine (~2H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG Ⅱ) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG Ⅱ.更多还原

【Abstract】 By means of cell culture, ~3H-thymidine (~2H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG Ⅱ) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG Ⅱ.更多还原

【关键词】 endothelin； angiotensin； atrial natriuretic peptide； c-fos oneogene； vascular smooth muscle cell.；
【Key words】 endothelin； angiotensin； atrial natriuretic peptide； c-fos oneogene； vascular smooth muscle cell.；

【文献出处】 Science in China,Ser.B ,中国科学B辑(英文版) , 编辑部邮箱 ,1993年08期

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