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人类前列腺特异性抗原p30在生殖免疫中的作用的探讨
The Influence of Prostate-Specific Antigen p30 on Human Fertility
【摘要】 作者采用自制的纯p30和抗p30单克隆及多克隆抗体,对前列腺特异性抗原p30在人类生殖与受孕中的作用进行了研究。实验结果表明:由p30产生的自身抗体对人类生殖过程无不良影响;由p30诱生制备的异种抗p30抗体在体外也不干扰人类生殖过程。由此提示p30不适宜推荐作为免疫避孕的疫苗抗原。
【Abstract】 The influence of prostate-specific antigen p30 on human fertility wasstudied with purified p30, domestic anti-p30 monoclocal and polyclonal antibodies.The results showed that the anti-p30 anti-body presented in human serum had nonegative effect upon human fertility andthe anti-p30 antibody produced by hetero-immunization did pot inierfere with theprocess of human fertility in vitro. All theseimply that it is unsuitable to recommendp30 as a contraceptive vaccine antigen.
【关键词】 人类前列腺特异性抗原p30;
免疫避孕;
人类生殖;
【Key words】 Prostate-specific antigen; Immunological contraception; Human fertility;
【Key words】 Prostate-specific antigen; Immunological contraception; Human fertility;
【基金】 国家计划生育委员会资助
- 【文献出处】 华西医科大学学报 , 编辑部邮箱 ,1993年04期
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