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肺癌患者与健康人血清Cu、Zn、Mn、Ni、Cr、Cd 含量及 Cu/Zn、Mn/Ni比值的对比分析

Contrast and Analysis on the Content of Cu Zn Mn Ni Cr Cd and the Ratio of Cu/Zn and Mn/Ni in the Serum of both the Patients with Lung Cancer and the Healthy Subjects

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【作者】 李开密张洪权闫素清吴予明刘洁蔡毅温伟丽杨新立梅其达高国谦张明智王志良

【Author】 Li Kaimi Department of Sanitary Analytical Chemistry,Henan Medical University,Zhengzhon 450052

【机构】 河南医科大学卫生分析化学教研室河南医科大学卫生分析化学教研室河南医科大学一附院肿瘤科

【摘要】 本研究用原子吸收分光光度计测定了肺癌患者与健康人血清 Cu、Zn、Mn、Ni、Cr、Cd 的含量。测定结果表明,肺癌患者人群的血清 Zn、Mn 值非常显著低于健康人(P<0.001),而血清 Cu、Ni、Cr 值则非常显著高于健康人(P<0.001).血清 Cd 值显著高于健康人(P<0.05)。提示上述六种微量元素都有可能与肺癌的发生或发展有一定关系。

【Abstract】 For the purpose of studying the relation between lung carcinoma and serum levels of the trace elements,the serum levels (μmol/L) of Cu Zn Mn Ni Cr and Cd of 26 patients with lung cancer and 27 healthy subjects (the control group) were determined with the atomic absorption spectrop- hotometer.The assay results showed that the levels of Zn and Mn of the patients were much lower than those of the healthy subjects (P<0.001),while the values of Cu Ni and Cr in serum were significantly higher than those of the healthy subjects (P<0.001),and the value of Cd was singnificantly higher than that of the healthy subjects (P<0.05).The results indicated that there may exist certain relationship between all the six trace elements mentioned above and the occurence or developmenl of lung cancer.

【关键词】 肺癌血清微量元素
【Key words】 lung cancerserumtrace element
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