【摘要】 本文报道了8例青年健康志愿者口服50mg麦普替林的药代动力学参数。麦普替林的药时曲线符合一室线性动力学模型,T_peak=12.03±8.41h;t_1/2ke=57.7±37.4h;CL=49.47±47.02 l/h;Vd=2754±1230 l。麦普替林的主要代谢产物去甲麦普替林的药时曲线亦符合一室线性动力学,其T_peak=9.55±7.54h;t_1/2ke=138.5±107.5h;CL=247.5±151.2 l/h;Vd=6577±3511 l。本文还对药代动力学参数的意义进行了讨论。更多还原

【Abstract】 Eight healthy young adult volunteers received single 50 mg oral doses of maprotilinehydrochloride tablet. The concentration-time curve of maprotiline fitted in with one compartment kinetic model. The parameters of maprotiline were as follows: Tpeak=12.03±8.41 h; t1/2ke=57.7±37.4h; CL=49.47±47.02 l/h; Vd=2754±1230 l. The concentration time curve of its metabolite,desmethyl maprotiline, fitted in with one compartment kinetic model. Tpeak=9.55±7.54 h; t1/2 ke=138.5±107.5 h; CL=247.5±151.2 l/h; Vd=6577±3511 l. The clinical significance of the pharmacoki-netic parameters was discussed.更多还原