【摘要】 将8名甲肝抗体阴性的6—8岁学龄儿童按常规种痘方法接种含甲肝病毒基因的重组痘苗病毒。接种后一个月痘苗与甲肝抗体全部阳转。免疫后二月甲肝抗体滴度为1:4～≥1:16,平均1:8(ELISA竞争抑制法)。中和抗体滴度为1:10～1:80。免后二年甲肝抗体仍保持阳性,滴度稍有下降。两年期间免疫儿童未发生甲肝病例;对照组8名儿童中1名患甲肝,另一名隐性感染。更多还原

【Abstract】 Eight children of 6—8 yrs old, who had never been immunized with vaccinia and were sero-negative to HAV, had a primary reaction of vaccinia after vaccination with a hepatitis A-vaccinia recombinant virus (VMS11HAV25). All the eight children showed sero-conversion to both HAV and vaccinia virus. The HAV antibody titers were 1:4--≥ 1:16 two months after vaccination in ELISA competition test and 1:10—-1:80 in neutralization test. HAV antibody remained positive 2 years after vaccination. None of them contracted hepatitis A during the observation period. Whilst among 8 nonvaccinated control children one contracted hepatitis A with detected HAV-IgM and another one caught an asymtomatic infection.更多还原