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人参皂甙Rb1、Rg1、Re及Rh1对人胚肺成纤维细胞的影响(Ⅰ)

EFFECT OF GINSENOSIDES Rb1、Rg1、Re AND Rh1 ON HUMAN EMBRYONIC LUNG FIBROBLASTS IN VITRO

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【作者】 刘平; 葛迎春; 王本祥; 王陆黎; 马兴元; 徐景达;

【Author】 Liu Ping, Ge Yingchun, Wang Benxiang(Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021.)

【机构】 吉林省中医中药研究院中药研究所; 白求恩医科大学化学教研室; 白求恩医科大学化学教研室 长春 130021; 长春 130021;

【摘要】 本研究应用细胞化学和显微分光光度术,定量观察了人参皂甙Rb1、Rg1、Re、Rh1对人胚肺成纤维细胞的影响,结果表明:四种单体皂甙与人参根总皂甙(SRG)作用相似,都可以提高高代龄细胞内多糖类、葡萄糖-6-磷酸脱氢酶(G-6-PDH)、乳酸脱氢酶(LDH)、琥珀酸脱氢酶(SDH)、丙酮酸氧化酶(PVO)及低代龄细胞内单胺氧化酶(MAO)的含量,同时降低高代龄细胞内MAO的含量。除Rh1外,其它样品均可以提高高代龄细胞内葡萄糖-6-磷酸酶(G-6-Pase)的含量。本文对上述变化的意义进行了讨论。

【Abstract】 Using the cytochemistry and cytospectrophotometry, we observed the effect of ginsenosides Rb、Rg1、Re and Rh1 on human embryonic lung fibroblasts. The results showed that seponins of Rb、Rg1、Re Rh1 were similar to saponins of ginseng roots (SRG) in pharmacal action, both of them enhanced the content of Polysaceharibe, Glucose—6—phosphate dehydrogenase (G—6—PDH), Lactate dehydrogenase (LDH), Succinate dehydrogenase (SDH) and Pyruvate oxidase (PVO) in a high passage cultwed and monoamine oxidase (MAO) in a low passage cultued, but at the same time decreased MAO ina high passage cultued.. All ginsenosides increased the content of Glucose—6—phosphatase (G—6—Pase) in a high passages cultured except Rh1. The significance mentioned above was discussed.

  • 【文献出处】 中国组织化学与细胞化学杂志 ,Chinese Journal of Histochemistry and Cytochemistry , 编辑部邮箱 ,1993年03期
  • 【被引频次】1
  • 【下载频次】56
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