【摘要】 随着新一代疫苗的发展,安全、高效的免疫佐剂的研究日益紧迫.本文介绍了这一领域的研究,扼要综述了高分子免疫佐剂的研究进展,并展望了高分子免疫佐剂的发展前景.更多还原

【Abstract】 With the development of the "new vaccine",i, e. , subunit and especially synthetic peptide vaccine, the need for a safe and efficacious immunoadjuvant has become paramount because of the weak immunogenicity of the pure antigens. In this paper we review the various approaches that are being explored for the development of a safe and efficacious immunological adjuvant aimed at specifically increasing both the humoral and cellular immune response to a desired vaccine antigen. Among these approaches, the polymer adjuvant is highlighted, which encompass those improving the presentation of the various antigen(by controlled release or altering the presentation states) as well as those stimulating the immune cells, i. e. , macrophages, T and/or B cells. It is expected that the biodegradable polymer immunoadjuvant is the most promising one that would be clinically acceptable in the near future.更多还原