【摘要】 为探讨糖基磷酰胺酯类化合物的抗肿瘤活性,用三氯氧磷作磷酰化试剂,合成了标题化合物.通过重结晶,分离出标题化合物的一个纯异构体.经X射线衍射单晶结构分析,该晶体属单斜晶系,空间群P2₁,a=1.3474（5）nm,b=1.0624（4）nm,c=1.6916（5）nm,β=110.55（3）°,z=4,D_x=1.35g/cm³.收集到独立衍射点4379个,其中2159个为可观测点.最终一致性因子R=0.079.结构分析结果表明,反应中形成的手性磷原子为R构型.更多还原

【Abstract】 To study the antitumor activity of galactopyranosyl phosphoramidate, the title compound was synthesized by phosphorus oxychloride as phosphorylating agent. A pure isomer of the title compound was obtained by recrystallization from a mixture of chloroform and n-hexane, and its single crystal was cultured. The molecular structure of the title compound was determined by X-ray diffraction method. The crystal is monoclinic with space group P21, a=1. 3474(5) nm, 6=1.0624(4) nm, c=1. 6916(5) nm, β=110.55(3)°, V=2. 2674 nm3, Mr = 463. 29, Z = 4, Dx=1. 35 g/cm3, μ=3.9 cm-1, F(000) = 972. A total of 4379 independent reflections were collected, in which 2159 were observed. The final R = 0. 079 and Rw = 0. 088. The results of structure analysis indicate that the configuration of the chiral phosphorus atom of the title compound is assigned as R-form.更多还原