【摘要】 <正> 顺铂（cis-DDP）和顺式1,1-环丁烷二羧基二胺合铂（Ⅱ）（即卡铂,CBDCA）具有良好的抗癌活性,其主要靶分子均为DNA。但这些配合物与DNA作用前必须首先通过细胞膜。离体肿瘤对顺铂的摄入要比卡铂快得多,海拉细胞（Helas-3）摄入顺铂的速度要比摄入K₂PtCl₄或K₂PtCl₆慢。Binks等研究了鼠小肠摄取顺铂和卡铂的动力学机理,指出这两种配合物更多还原

【Abstract】 In the synthetic plasma, the uptake kinetics of cis-platin and it’ s related compounds in human erythrocytes was studied. The experimental results show that the across-membrane transport of all the platinum compounds studied follows a first-order kinetic process in the initial stage. The entry of these compounds into the human red blood cell is considered to follow a passive diffusion mechanism. The uptake rate constants of seven platinum( Ⅱ ) compounds were determined. The uptake rates are related to the polarity, charge and hydrolysis rate of the coordination compounds.更多还原