A configuration of differential photothermal refraction was presented by using a focal lens for compensation of the divergence of the probe beam. it eliminatce the solvent effect on the absorpiton and intensity fluctuation and point noise in pump source. This configuration of the optical system is simple ,and,the adjustment of the sample and the reference cell is achieved easily. The detailed experimental parameter of photothermal refraction spectrometry was discussed. The detection limit of 1. 0×10-9 mol/L...