【摘要】 本文报导奥美拉唑(Ome)治疗消化性溃疡及伴发慢性胃炎(CG)、幽门螺杆菌(HP)感染80例近期疗效的临床研究结果。以 Ome 20mg/日与法莫替丁(Fam)40mg/日分组治疗四周作对比研究,发现 Ome 不仅对十二指肠溃疡(Du)、胃溃疡(Gu)的愈合率(86.8%、70.4%)优于 Fam(P<0.05),而且对伴发的慢性胃炎、幽门螺杆菌感染的疗效也明显优于 Fam。Ome 对 Du、Gu伴发 CG 总有效率分别为81.1%、85.2%,高于 Fam(36.4%、29.4%)P<0.01;Ome 对 Du、Gu 伴发的 HP 感染总有效率分别为83.0%、81.5%,而 Fam仅分别为21.2%、17.7%,差异非常显著(P<0.01)。上述结果提示,奥美拉唑不仅有卓越的愈合溃疡作用,对溃疡伴发的慢性胃炎、幽门螺杆菌感染亦有显著疗效。更多还原

【Abstract】 One hundred and thirty patients with endoscopically documented active peptic ulcer,and it’s accompanied chronic gastritis(CG)and helicobacter pylori(HP)infection were divided into two groups.80 patients were treated with omeprazole 20 mg P.O.;and 50 patients were treated with famtidine(Fam)40 mg P.O.After a course of four weeks treatment,the healing rate of duodenal and gastric ulcer(Gu)were 86.8% and 70.4% in omeprazole group but were 63.6% and 47.1% in the famtidine.The therapeutic effective rate of CG accompanied with DU anb GU(81.1%,85.2% respectively)in omeprazole group were higher than in famtidine group(36.4%,29.4% respectively).The disappearing rate of HP in omeprazole group were significantly higher(DU 83.0%,Gu 81.5% respectively)than Fam group(DU 21.2%)Gu 17.7% respectively) also.In conclusion:omeprarole is a very effective drug not only for the peptic ulcer but also for it’s accompanied chronic gastritis and helicobacter pylori infection.更多还原