【摘要】 用连续支气管肺泡灌洗的方法测定了染尘(2mg石英)2～18周大鼠灌洗液中细胞总数、巨噬细胞、白细胞及可溶性蛋白。结果表明,于染尘后,各项指标均明显增高,可溶性蛋白是对照组的5～9倍,细胞总数是7～17倍,巨噬细胞是1.5～5倍,白细胞所占百分比均超过细胞总数的50％(对照均少于4％)。同时测定了染尘和对照大鼠肺内细胞及蛋白质的灌洗功效。更多还原

【Abstract】 The number of total free cells, alveolar macrophages (AM), polymorphonuclear Ieukocytes (PMN)and soluble protein from the lungs of silica-treated (2mg DQ12/rat) and control rats by 6 time sequ-ential bronchoalveolar lavage (BAL) were determined at various time 2～18 weeks after exposure.Highly significant increases were observed in soluble protein (5～9-fold), the total free cells (7～17-fold), AM (1.5～5-fold) and PMN more than 50％ (control less than 4％). The efficacy of BAL inthe removal of cell and soluble protein of lining layer from the lungs of silica-treated and controlrats was also determined.更多还原