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急性白血病形态学和免疫学及细胞遗传学分型分析

AN ANALYSIS OF MORPHOLOGIC, IMMUNOLOGIC AND CYTOGENETIC CLASSIFICATION IN CASES WITH ACUTE LEUKEMIA

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【作者】 王德炳邓星明陈珊珊丘镜滢吴平娜付剑锋单福香江滨史琪任汉云刘素贤陆道培

【Author】 Wang Debing Institute of Hematology

【机构】 北京医科大学血液病研究所北京医科大学血液病研究所

【摘要】 本文从形态学、免疫学和细胞遗传学(MIC)三方面系统观察了31例初治成人急性白血病,结果表明,形态学与细胞化学符合率84%,FAB分型与免疫学分型符合率93.5%,FAB分型与MIC分型符合率为96.8%,免疫学分型与MIC分型符合率亦为96.8%。在27例AML中,淋巴细胞抗原阳性(Ly~+-AML)6例,占22.2%。31例急性白血病中染色体核型异常15例,占48.4%。

【Abstract】 We observed morphologic, immunologic, and cytogenetic classification in 31 untreated adult pati-ents with acute leukemia. It was found the correspondence rate between morphology and cytochemistrywas 84%, the correspondence rate between FAB classification and immunologic classification was93.5%, and the correspondence rate between. immunologic classification and MIC classification was96.8K. Among 27 patients with acute myelogenous leukemia (AML), six cases showed lymphocyteantigen-positive (22.2%). Of 31 cases of acute leukemia, 15 showed chromosome karyotypic abnorma-lities (48.4%). Of 13 cases of AML-M2, 5 had t(8;21). Of 8 cases of AML-M3, 3 had t(15; 17).Amnog 4 patients with acute lymphocytic leukemia, one had t(9; 22), one had t(9; 15; 22).

【关键词】 形态学免疫学遗传学白血病
【Key words】 MorphologyImmunologyCytogeneticsAcute leukemia
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