【摘要】 报道42例急性髓性白血病（AML）骨髓活检切片改良FAB分类之结果,并与涂片作比较,证明两种标本的M₃型一致,涂片M_2a较切片为高,切片内M₄亚型较涂片为高,42例中的13例切片内原始细胞数较涂片为高,提示活检切片对涂片起有补充与纠正作用。更多还原

【Abstract】 We report the modified FAB classification of bone marrow biopsy specimens and comparison withbone marrow smears,taken simultaneously from 42 patients with acute myeloid leukemia （AML）. Aconsiderable difference was observed between the results of one--step aspirate smears and the findings of biopsy section. Concordance between the aspirate and biopsy specimen M₃ was observed in 13 cases.But the cases of myeloblastic leukemia with maturation (M_2a) in aspirate smears was higher than thatestimated in the sections（13: 9）, whereas the cases of myelomonocytic （M₄） variety was higher insection than in the aspirate smears （6: 4）. Three of the 13 cases classified as M_2a on the aspirateshowed some cells with morphological features of monoblasts in the sections and suggest M₄. Theabsence of monocytic components in smears may be an example of selective resistance to aspiration. Aconsiderable difference in the extent of blast cell infiltration was also observed between the smears andsections. In thirteen of the 42 cases the extent of cell infiltration was higher in sections than in thesmears. Our study shows that bone marrow biopsy complements and corrects the findings of marrowaspiration in the classification of AML.更多还原