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HLA抗原与脑血栓关联的研究
STUDY OF ASSOCIATION OF HLA WITH CEREBROVASCULAR DISEASE
【摘要】 本文用标准微量淋巴细胞毒试验及62种HLA抗血清对青岛地区56例脑血栓病人的HLA-A-B-Cω抗原进行了测定,并以72例健康人作对照。结果发现,脑血栓组HLA-A68,B5,B16,Cω10相对危险率高于对照组,经相对危险率x2检验,只有HLA-B5抗原(P<0.05)和HLA-B16(P<0.05)有统计学意义。提示青岛地区脑血栓病人可能与HLA-B5,B16抗原相关联。但由于标本量少,经校正后P>0.05,所以对脑血栓与HLA抗原关联的研究有待进一步深入。
【Abstract】 Fifty-six patients with cerebrovascular disease in Qingdao area were typed for 62HLA-A, B, Cω typing serum by NIH standard lymphcytoxic test. 72 healthy individualsserved as controls. The results showed that the frequency of HLA-A68, B5, B16, Cω10was higher in the patients than in the controls. By the relative risk (RR) x2 test, HLA-B5 antigen (P<0.05) and HLA-B16 antigen (P<0.05) were found to have remarkablesignificance. The results indicate that carebrovascular disease in Qingdao area may beassociated with HLA-B5 and B16 antigens. But as Pc>0.05, further research has to bemade.
- 【文献出处】 青岛医学院学报 , 编辑部邮箱 ,1993年03期
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