【摘要】 用碱洗脱技术观察了国产洋红霉素（CMN）引起小鼠淋巴白血病P₃₆₈细胞单链DNA的断裂作用。在CMN0.25—2.0μg/ml范围内,这种作用是剂量依赖性的。电镜观察研究CMN对P₃₈₈细胞核仁超微结构的影响。CMN 1.0μg/ml作用2小时,核仁空泡增多、微球体出现;作用4小时;核仁“帽”形成;作用8小时,部分细胞核仁成分碎裂。更多还原

【Abstract】 With alkaline elution assay, effects of domestic carminomycin on DNA single-strand breaks were observed in leukemia P388 cells. The effects were dose-dependent, timedepen dent and irreversible. Under electron microscope, it was obser/ced that carmino mycin caused a nucleolar "Cap" forming and a nucleolar segregation or fragmentation.更多还原