【摘要】 本文使用图像分析技术测定55例胃癌的核DNA相对含量。按照DNA组方图的弥散程度,将DNA倍体类型分为三种。Ⅰ型:二倍体或近二倍体区域有一明确的峰值;Ⅱ型:主要峰值位于四倍体或近四倍体处:Ⅲ型:广泛弥散无明确峰值出现。研究结果提示:弥漫型胃癌主要为Ⅰ型,而肠型胃癌则往往为高异倍体型。早期与进展期胃癌的倍体类型无明显差别,早期胃癌病例的DNA含量并不比进展期胃癌高。这个结论提示:肿瘤倍体类型在肿瘤发展早期即已决定,并不随肿瘤演进而改变。同时我们还发现DNA分布类型与肿块大小、淋巴结转移均无关。更多还原

【Abstract】 Relative DNA content in gastric carcinoma was measured by automatic imageanalysis technique. According to the dispersion on the DNA histogram, DNA ploidypatterns were classified into three types: 1.diploid or near-diploid; 2. tetraploid ornear-tetraploid;3. aneuploid. The results showed that diffuse type carcinoma was pre-dominantly diploid. By contrast, most intestinal type was aneuploidy. No significantdifference in the ploidy patterns had been found between early and advanced carcino-mas. Early gastric cancer didn’t tend to contain a lesser amount of DNA thanthe advanced ones indicating ploidy pattern of carcinoma might be settled in anearly stage of tumor development, and did not change easily in tumor progression.Moreover, no relationship was found between DNA distribution pattern and tumor sizeand 1ymph node metastasis.更多还原